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Comanche activist LaDonna Harris has been advocating for Indigenous cultural, economic and political power since the 1960s, inspiring Native leadership around the world to fight against marginalization and discrimination. Director Julianna Brannum, LaDonna's great niece, traces the indelible legacy of her kin, celebrating Harris’ life and work as the founder of Americans for Indian Opportunity, her instrumental role in returning sacred territory to Indigenous hands, and her drive to bring Native American perspectives into the mainstream. As clashes between colonial and Indigenous values flare around the globe, LaDonna Harris: Indian 101 sheds light on the rewards and complexities of struggling for political change.